Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.
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چکیده
منابع مشابه
Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.
The efficacy of methylprednisolone (1 g daily or three days), which is effective in reversing transplant rejection, was assessed in a randomised controlled trial of 55 patients with severe acute alcoholic hepatitis, 34 of whom had encephalopathy. The clinical progress, frequency of bleeding and sepsis, and cause of death were similar in the treatment (27 patients) and control groups (28 patient...
متن کاملClinical trial Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis
The efficacy of methylprednisolone (1 g daily for three days), which is effective in reversing transplant rejection, was assessed in a randomised controlled trial of 55 patients with severe acute alcoholic hepatitis, 34 of whom had encephalopathy. The clinical progress, frequency of bleeding and sepsis, and cause of death were similar in the treatment (27 patients) and control groups (28 patien...
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Severe alcoholic hepatitis (sAH) is associated with a poor prognosis. There is no proven effective treatment for sAH, which is why early transplantation has been increasingly discussed. Hepatoblastoma-derived C3A cells express anti-inflammatory proteins and growth factors and were tested in an extracorporeal cellular therapy (ELAD) study to establish their effect on survival for subjects with s...
متن کاملPentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial.
BACKGROUND & AIMS An earlier pilot study from our liver unit suggested benefit from treatment with pentoxifylline (PTX), an inhibitor of tumor necrosis factor (TNF), in severe acute alcoholic hepatitis. The aim of the present study was to evaluate this treatment in a larger cohort of patients. METHODS One hundred one patients with severe alcoholic hepatitis (Maddrey discriminant factor > or =...
متن کاملPentoxifylline in severe alcoholic hepatitis: a prospective, randomised trial.
BACKGROUND Role of corticosteroids in treatment of severe alcoholic hepatitis (SAH) is controversial. Pentoxifylline (PTX), an inhibitor of TNF, has also been shown to decrease short term mortality in SAH. Aim of this study was to evaluate the effect of PTX on short term mortality, renal and hepatic functions in patients with SAH. METHODS Fifty patients with SAH {Maddrey's Discriminant Functi...
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ژورنال
عنوان ژورنال: Gut
سال: 1982
ISSN: 0017-5749
DOI: 10.1136/gut.23.1.75